| 响应面法优化海藻多糖菊粉泡腾片润滑剂种类及添加量 |
| |
| 引用本文： | 蒲洋,冯大伟,包焕玲,秦松,衣悦涛.响应面法优化海藻多糖菊粉泡腾片润滑剂种类及添加量[J].食品科学,2012,33(12):93-96. |
| |
| 作者姓名： | 蒲洋 冯大伟 包焕玲 秦松 衣悦涛 |
| |
| 作者单位： | 1.中国科学院烟台海岸带研究所
2.中国科学院研究生院
3.山东东方海洋科技股份有限公司 |
| |
| 基金项目： | 中国科学院创新团队国际合作伙伴计划项目;中科院知识创新工程重要方向项目(KZCX2-YW-225);国家科技支撑计划项目(2011BAC02B04) |
| |
| 摘 要： | 以有机富硒海藻多糖、菊粉原料，采用无水乙醇酸碱两相制粒法，制备富硒海藻多糖菊粉泡腾片。通过3因素3水平的Box-Behnken试验设计及响应面试验优化硬脂酸镁、十二烷基硫酸钠、微粉硅胶润滑剂在配方中添加量；最优配方为硬脂酸镁添加量0.70%、十二烷基硫酸钠添加量2.60%、微粉硅胶添加量0.90%。对最终产品进行质量分析，结果表明：所得产品制粒、压片效果好，各项指标均符合《中华人民共和国药典》相关规定。
|
| 关 键 词： | 泡腾片 配方优化 菊粉 有机富硒海藻多糖 |
Optimization of Lubricant Typye and Amount in Seaweed Polysaccharide-Inulin Effervescent Tablets by Response Surface Methodology |
| |
| PU Yang,FENG Da-wei,BAO Huan-ling,QIN Song,YI Yue-tao.Optimization of Lubricant Typye and Amount in Seaweed Polysaccharide-Inulin Effervescent Tablets by Response Surface Methodology[J].Food Science,2012,33(12):93-96. |
| |
| Authors: | PU Yang FENG Da-wei BAO Huan-ling QIN Song YI Yue-tao |
| |
| Affiliation: | (1. Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China；2. Graduate University of
Chinese Academy of Sciences, Beijing 100049, China；3. Shandong Oriental Ocean Sci-tech Co. Ltd., Yantai 264003, China) |
| |
| Abstract: | Effervescent tablets were prepared from organic selenium-enriched seaweed polysaccharides and inulin by absolute alcohol-acid-base two-phase granulation method.Using response surface methodology based on a three-variable,three-level central composite design,the amounts of the added lubricants sodium dodecylsulfate,magnesium stearate,and silica powder in effervescent tablet formulation were optimized to be 0.70%,2.60% and 0.90%,respectivley.All the quality indexes fhe prepared effervescent tablets complied with the requirements of the Chinese Pharmacopoeia. |
| |
| Keywords: | effervescent tablets optimum formulation inulin organic selenium-enriched seaweed polysaccharide |
| 本文献已被 CNKI 等数据库收录！ |
| 点击此处可从《食品科学》浏览原始摘要信息 |
|
点击此处可从《食品科学》下载全文 |
|
