| 卡波姆凝胶的优化研究方法 |
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| 引用本文： | 朱颐申,胡一桥,韦萍,周华,欧阳平凯. 卡波姆凝胶的优化研究方法[J]. 陶瓷科学与艺术, 2002, 0(4) |
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| 作者姓名： | 朱颐申 胡一桥 韦萍 周华 欧阳平凯 |
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| 作者单位： | 南京工业大学制药与生命科学学院 江苏南京210009(朱颐申，韦萍，周华)，中国药科大学药剂教研室 江苏南京210009(胡一桥)，南京工业大学制药与生命科学学院 江苏南京210009(欧阳平凯) |
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| 摘 要： | 以卡波姆水凝胶为考察对象。采用多元线性回归正交设计实验方案 ,选择凝胶粘度与塑变值 (作为考核指标 ) ,选择卡波姆浓度、Na Cl浓度、p H值作为影响因素 ,优化筛选卡波姆水凝胶。分别得到粘度及塑变值优化方程 ,经过系数检验、方程检验、失拟检验证明以上两个方程不失拟 ,置信度均为 95 %。 3种因素中 ,p H在 4～ 8范围内对粘度和塑变值的影响最小 ,卡波姆及 Na Cl浓度的影响接近。
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| 关 键 词： | 水凝胶 多元线性回归正交设计 卡波姆941 |
Optimized design method of Carbomer |
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| ZHU Yi shen ,HU Yi qiao ,WEI Pin ,ZHOU Hua ,OUYANG Ping kai College of Life Science and Pharmacy,Nanjing University of Technology,Nanjing ,China China Pharmaceutical University,Nanjing ,China). Optimized design method of Carbomer[J]. Ceramics Science & Art, 2002, 0(4) |
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| Authors: | ZHU Yi shen HU Yi qiao WEI Pin ZHOU Hua OUYANG Ping kai College of Life Science Pharmacy Nanjing University of Technology Nanjing China China Pharmaceutical University Nanjing China) |
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| Affiliation: | ZHU Yi shen 1,HU Yi qiao 2,WEI Pin 1,ZHOU Hua 1,OUYANG Ping kai 11College of Life Science and Pharmacy,Nanjing University of Technology,Nanjing 210009,China 2 China Pharmaceutical University,Nanjing 210009,China) |
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| Abstract: | A series of hydrogel were prepared by Carbomer material. Multi linear orthogonal regression design was used to optimize the hydrogel preparation methods. The viscosity and the yield value were two indexes indicated the hydrogel properties. The influence of the Carbomer concentration, NaCl concentration and pH were considered in the design. The optimized models of the viscosity and the yield value are obtained. Both the confidence limits were 95%. In the three factors, the influence of pH was the least to the viscosity and the yield value; the influences of the Concentrations of carbomer and of NaCl were close with each other. |
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| Keywords: | hydrogel multi linear orthogonal regression design Carbomer 941 |
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