| 3-甲硫基苯胺的制备 |
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| 引用本文： | 任戎,张翌,刘登科,王松青. 3-甲硫基苯胺的制备[J]. 精细化工中间体, 2006, 36(4): 16-17,20 |
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| 作者姓名： | 任戎 张翌 刘登科 王松青 |
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| 作者单位： | 天津大学,药物科学与技术学院,天津,300072;天津药物研究院,天津,300193;天津药物研究院,天津,300193;天津大学,药物科学与技术学院,天津,300072 |
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| 摘 要： | 以硝基苯为起始原料,经氯磺化反应、还原反应(KI/H3PO3)、还原反应(Na2S)、甲基化反应、还原反应(Fe/HCl),制得3-甲硫基苯胺(1)。优化了反应条件,简化了操作,总收率50.3%,纯度99.1%(HPLC)。
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| 关 键 词： | 3-甲硫基苯胺 还原反应 制备 双(3-硝基苯基)二硫化物 |
| 文章编号： | 1009-9212（2006）04-0016-02 |
| 收稿时间： | 2006-05-09 |
| 修稿时间： | 2006-05-09 |
Preparation of 3-(Methylthio)benzenamine |
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| REN Rong,ZHANG Yi,LIU Deng-ke,WANG Song-qing. Preparation of 3-(Methylthio)benzenamine[J]. Fine Chemical Intermediates, 2006, 36(4): 16-17,20 |
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| Authors: | REN Rong ZHANG Yi LIU Deng-ke WANG Song-qing |
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| Affiliation: | 1. College of Pharmaceuticals and Biotechnology, Tianjin University, Tianjin 300072, China; 2. Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China |
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| Abstract: | 3-(Methylthio)benzenamine(1)was obtained from nitrobenzene through 5-step reactions including chlorosulfonation,reduction with KI/H3PO3,reduction with Na2S,methylation and reduction with Fe/HCl. The overall yield was 50.3%,and purity 99.1%(HPLC). The procedure developed had several advantages of facile reaction conditions,convenient operation and cheap reagents. |
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| Keywords: | 3-(methylthio)benzenamine reduction preparation bis(3-nitrophenyl)disulfide |
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