| 6-甲基-4-氯-7-硝基-3-氰基喹啉的合成 |
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| 引用本文： | 刘宝,尤启冬.6-甲基-4-氯-7-硝基-3-氰基喹啉的合成[J].化学试剂,2009,31(11). |
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| 作者姓名： | 刘宝 尤启冬 |
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| 作者单位： | 中国药科大学,药物化学教研室,江苏,南京,210009 |
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| 基金项目： | 国家自然科学基金资助项目 |
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| 摘 要： | 以对甲基苯胺为起始原料,经过硝化、缩合、Gould-Jacobs环合和氯化反应,首次合成了标题化合物,总收率约20%.用EI-MS、1HNMR等确定了目标化合物的结构.
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| 关 键 词： | 6-甲基-4-氯-7-硝基-3-氰基喹啉 硝化 Gould-Jacobs环合反应 合成 |
Synthesis of 6-methyl-4-chloro-7-nitro-3-carbonitrile quinoline |
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| LIU Bao,YOU Qi-dong.Synthesis of 6-methyl-4-chloro-7-nitro-3-carbonitrile quinoline[J].Chemical Reagents,2009,31(11). |
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| Authors: | LIU Bao YOU Qi-dong |
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| Abstract: | A new compound 6-methyl-4-chloro-7-nitro-3-carboni-trile quinoline was synthesized from 4-methylaniline via four steps, including selective nitration, condensation, the Gould-Ja-cobs reaction,and chlorination.The total product yield was 20% . The product structures were confirmed by mass spectrometry and ~1HNMR spectrometry. |
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| Keywords: | 6-methyl-4-chloro-7-nitro-3-carbonitrile quinoline nitration Gould-Jacobs reaction synthesis |
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