Chemistry and health effects of polymethoxyflavones and hydroxylated polymethoxyflavones |
| |
Authors: | Shiming Li Min-Hsiung Pan Chih-Yu Lo Di Tan Yu Wang Fereidoon Shahidi Chi-Tang Ho |
| |
Affiliation: | 1. Department of Food Science, Rutgers University, New Brunswick, NJ 08901, USA;2. Department of Seafood Science, National Kaohsiung Marine University, Kaohsiung 811, Taiwan;3. Department of Food Science, National Chiayi University, No. 300 Syuefu Road, Chiayi 600, Taiwan;4. Department of Biochemistry, Memorial University of Newfoundland, St. John’s, NL, Canada A1B 3X9;5. Graduate Institute of Food Science and Technology, National Taiwan University, Taipei, Taiwan |
| |
Abstract: | Polymethoxyflavones (PMFs) and hydroxylated polymethoxyflavones exist exclusively in citrus genus, especially in the citrus peels which have been used as herbal medicine for several diseases for thousands of years. In this review, the natural occurrence, isolation and separation of PMFs; synthetic scheme of hydroxylated PMF preparation, especially the reaction mechanism of preparation of 5-hydroxylated PMFs; biotransformation and metabolic fate of PMFs; the preliminary study on PMF bioavailability and the close relationship among solubility, permeability, absorption and oral bioavailability are summarized. The published bioactivity data on anti-inflammatory, anti-cancer and anti-atherogenic properties of PMFs have also been detailed along with a report of new findings of hydroxylated PMFs and their potent biological activities. |
| |
Keywords: | |
本文献已被 ScienceDirect 等数据库收录! |
|