Porcine artery elastin preparation reduces serum cholesterol level in rats |
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Authors: | Ruvini Liyanage Yumi Nakamura Ken-ichiro Shimada Mitsuo Sekikawa Barana Chaminda Jayawardana Kyu-Ho Han Tomoko Okada Kiyoshi Ohba Yoshihisa Takahata Fumiki Morimatsu Michihiro Fukushima |
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Affiliation: | 1. Department of Food Science, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080-8555, Japan;2. Department of Animal Science, Faculty of Agriculture, University of Peradeniya, Sri Lanka;3. Hokkaido Tokachi Area Regional Food Processing Technology Center, Obihiro, Hokkaido 080-2462, Japan;4. R&D Center, Nippon Meat Packers, Inc., Tsukuba, Ibaraki 300-2646, Japan |
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Abstract: | The effect of porcine artery elastin on serum cholesterol level was investigated in rats fed a cholesterol-free diet. Rats were fed for 4 weeks, with a diet (ED) containing 15% casein and 5% of porcine artery elastin in comparison with a diet (CD) containing 20% casein. The total serum and non-HDL-cholesterol concentrations were lower (P < 0.001) in ED-fed group than the CD-fed group at the end of the experiment. Caecal propionate concentration and Bifidobacterium and Lactobacillus population were higher (P < 0.05) in ED-fed group than the CD-fed group. The results of this study suggest that porcine artery elastin could be considered as a functional dietary protein with hypocholesterolaemic ability. Favourable amino acid composition and lysine derived cross links may at least be partially responsible for the hypocholesterolaemic ability of ED. Moreover, the higher caecal propionic acid concentration in the ED-fed group may have suppressed the cholesterol synthesis in the liver, and reduced the serum cholesterol level. |
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