Simple Prediction of Stability Constants for Inclusion Complexes of β-Cyclodextrin with various Drug Molecules Using β-Cyclodextrin Bonded Phases(Cyclobond® I Column) |
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| Authors: | Mingxin Wang Haruhisa Ueda Tsuneji Nagai |
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| Affiliation: | a Faculty of Pharmaceutical Sciences, Hoshi University, Shinagawa-ku, Tokyo, Japanb China National Institute of Pharmaceutical R&D, Beijing, China |
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| Abstract: | The stability constants(Kc) for inclusion complexes of cyclodextrin with sulfonamides, sulfonylureas and p-aminobenzoic acid esters were investigated by high performance liquid chromatography (HPLC) using the cyclodextrin bonded phase. The retention time(Rt) of these drugs on a Cyclobond® I column showed a good relationship to K, values obtained by the solubility method and/or conventional HPLC method. The advantages of this method were that the K, values could be rapidly predicted by a simple procedure using a minimum quantity of the drugs. |
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