Upregulation of actin gene expression in cells expressing exogenous beta-amyloid precursor protein |
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| Authors: | N Ramakrishna M Smedman V Ramakrishna B Gillam |
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| Affiliation: | NYS Institute for Basic Research in Developmental Disabilities, Staten Island 10314, USA. |
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| Abstract: | We investigated the effects of beta-amyloid peptide precursor (APP) overexpression upon the levels of other mRNAs. Using quantitative slot-blot hybridization and immunoblot analysis we observed that enhanced levels of APP elevated the levels of beta-actin and beta-actin mRNA. Our results also suggest that the cytoplasmic domain of APP is crucial for the elevation in beta-actin gene expression. |
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