Gadolinium‐Doped Persistent Nanophosphors as Versatile Tool for Multimodal In Vivo Imaging |
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| Authors: | Thomas Maldiney Bich‐Thuy Doan Damien Alloyeau Michel Bessodes Daniel Scherman Cyrille Richard |
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| Affiliation: | 1. Unité de Technologies Chimiques et Biologiques pour la Santé (UTCBS), CNRS UMR 8258, Paris, France;2. Université Paris Descartes, Sorbonne Paris Cité Faculté des Sciences Pharmaceutiques et Biologiques, Paris, France;3. Chimie‐ParisTech, Paris, France;4. Laboratoire Matériaux et Phénomènes Quantiques, Université Paris Diderot, Paris, France |
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| Abstract: | Recent breakthroughs in the rational development of multifunctional nanocarriers have highlightened the advantage of combining the complementary forces of several imaging modalities into one single nanotool fully dedicated to the biomedical field and diagnosis applications. A novel multimodal optical‐magnetic resonance imaging nanoprobe is introduced. Designed on the basis of a spinel zinc gallate structure doped with trivalent chromium and gadolinium, this nanocrystal bears the ability to serve as both a highly sensitive persistent luminescence nanoprobe for optical imaging, and a negative contrast agent for highly resolved magnetic resonance imaging (MRI). Additional proof is given that surface coverage can be modified in order to obtain stealth nanoparticles highly suitable for real‐time in vivo application in mice, showing delayed reticulo‐endothelial uptake and longer circulation time after systemic injection. |
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| Keywords: | persistent luminescence nanoparticle magnetic resonance imaging optical imaging in vivo |
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