Mussel Byssus‐Like Reversible Metal‐Chelated Supramolecular Complex Used for Dynamic Cellular Surface Engineering and Imaging |
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Authors: | Wen Li Wei Bing Sa Huang Jinsong Ren Xiaogang Qu |
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Affiliation: | 1. Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin, China;2. University of Chinese Academy of Sciences, Beijing, China;3. Department of Radiology, The Second Hospital of Jilin University, Changchun, Jilin, China |
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Abstract: | Inspired by the load‐bearing biostructures in nature, a multifunctional shell for encapsulating cell using the polyphenol–metal complexes is fabricated. The artificial shell is formed by cross‐linking of tannic acid and iron ion on cell surface. It can protect cells from unfriendly environments, including UV light irradiation and reactive oxygen damage. With the hybrid property of polyphenol and metal liands, the shell provides a versatile platform for cell surface engineering. The magnetic nanoparticles, DNA molecules, as well as the magnetic resonance imaging agents are easily incorporated into the shell. More interestingly, unlike the traditional passive coatings, here the shell can be controllably disassembled under external stimuli. The dynamic coating is used as a reversible element to regulate cell division and surface modification. The cell viability and protein expression experiments further confirm that the shell formation and degradation processes are biocompatible. This multifunctional coating strategy is applicable to multiple living cell types, including yeast cells, Escherichia coli bacteria, and mammalian cells. Therefore, this platform would be useful for living cell based fundamental research and biological applications. |
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Keywords: | cell protection metal chelation stimuli‐responsiveness supramolecular complexes surface engineering |
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