| 冷冻抽提相分离法制备聚乳酸多孔支架 |
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| 引用本文： | 焦简金,丁晓红,郑璇,卢艺华,刘榕芳,肖秀峰.冷冻抽提相分离法制备聚乳酸多孔支架[J].功能材料,2011,42(Z3):567-572. |
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| 作者姓名： | 焦简金 丁晓红 郑璇 卢艺华 刘榕芳 肖秀峰 |
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| 作者单位： | 福建师范大学化学与材料学院,福建省高分子材料重点实验室,福建,福州,350007 |
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| 基金项目： | 国家自然科学基金资助项目(30600149,30970887); 卫生部科学研究基金资助项目(WJK2008-02-037) |
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| 摘 要： | 为了制备结构和性能满足骨组织工程支架要求的聚乳酸(PLA)多孔支架材料,采用冷冻抽提相分离法,以1,4-二氧六环和水为混合溶剂,聚乙二醇(PEG)为致孔剂,制得一系列PLA多孔支架,探讨了溶剂组成、PLA浓度、PEG添加量对PLA多孔支架结构和性能的影响,结果表明添加PEG有利于形成多孔三维支架,随着PEG含量的增加,...
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| 关 键 词： | 聚乳酸 聚乙二醇 多孔支架 冷冻抽提相分离 |
Fabrication of polylactide porous scaffolds by frozen extraction phase separation method |
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| JIAO Jian-jin,DING Xiao-hong,ZHENG Xuan,Lu Yi-hua,LIU Rong-fang,XIAO Xiu-feng.Fabrication of polylactide porous scaffolds by frozen extraction phase separation method[J].Journal of Functional Materials,2011,42(Z3):567-572. |
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| Authors: | JIAO Jian-jin DING Xiao-hong ZHENG Xuan Lu Yi-hua LIU Rong-fang XIAO Xiu-feng |
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| Affiliation: | JIAO Jian-jin,DING Xiao-hong,ZHENG Xuan,Lu Yi-hua,LIU Rong-fang,XIAO Xiu-feng(Fujian Key Laboratory of Polymer Materials,College of Chemistry and Materials Science,Fujian Normal University,Fuzhou 350007,China) |
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| Abstract: | To prepare the polylactide(PLA) porous scaffolds whose structure and property could meet the needs of bone tissue engineering,a series of PLA porous scaffolds were prepared by frozon extraction phase separation method with using 1,4-dioxane and water as the blend solvent and poly(ethylene glycol)(PEG) as the porogen.The effect of solvent composition,PLA concentration and the amount of PEG on the structure and property were studied.The results showed that the addition of PEG was benificial for forming three-... |
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| Keywords: | polylactide polyethylene glycol porous scaffold frozen extraction phase separation |
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