Immunomodulation by polyunsaturated fatty acids: Impact on T-cell signaling |
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Authors: | Email author" target="_blank">Thomas?M?StulnigEmail author Maximilian?Zeyda |
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Affiliation: | Division of Endocrinology and Metabolism, Department of Internal Medicine III, University of Vienna, Vienna, Austria. Thomas.Stulnig@meduniwien.ac.at |
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Abstract: | In recent years the potential application of the immunomodulatory effects of polyunsaturated FA (PUFA), particularly those
of the n−3 series, in a variety of inflammatory disorders has been of considerable interest. However, the mechanisms underlying
inhibition of T-cell activation have so far been unclear. In this short review we summarize possible mechanisms for the modulation
of immune responses by PUFA. Effects of PUFA on T-cell signal transduction pathways and underlying molecular mechanisms are
described in detail. These recent results add considerably to the understanding of mechanisms of PUFA actions, but their relevance
in the in vivo situation must still be elucidated. |
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