| 6-氯-2(1H)-吡啶酮的合成和表征 |
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| 引用本文： | 郑淑玲,张明华,赵增国. 6-氯-2(1H)-吡啶酮的合成和表征[J]. 精细石油化工, 2006, 23(2): 48-50 |
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| 作者姓名： | 郑淑玲 张明华 赵增国 |
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| 作者单位： | 天津师范大学化学与生命科学学院,天津,300074 |
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| 摘 要： | 以吡啶为起始原料,先经光氯化法合成中间体2,6-二氯吡啶,最佳反应条件是：n(吡啶)：n(氯气)= 1：2．2,氯化温度为190～210℃,再以乙醇为介质在加压下时行醇解合成了6-氯-2(1H)-吡啶酮,产率达85%,通过元素分析、红外光谱、质谱等对6-氯-2(1H)-吡啶酮的结构进行了表征。
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| 关 键 词： | 吡啶 光氯化2，6-二氯吡啶 6-氯-2(1H)-吡啶酮 |
| 收稿时间： | 2005-09-14 |
| 修稿时间： | 2006-02-03 |
SYNTHESIS AND CHARACTERIZATION OF 6-CHLORO-2(1H)-PYRIDINOL |
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| Zheng Shuling,Zhang Minghua,Zhao Zengguo. SYNTHESIS AND CHARACTERIZATION OF 6-CHLORO-2(1H)-PYRIDINOL[J]. Speciality Petrochemicals, 2006, 23(2): 48-50 |
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| Authors: | Zheng Shuling Zhang Minghua Zhao Zengguo |
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| Affiliation: | College of Chemistry and Life Science, Tianjin Normal University, Tianjin 300074, China |
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| Abstract: | 2,6-Dichloropyridine was synthesized from chlorination of pyridine under UV irradiation in the presence of chlorine under the optimal conditions:pyridine:chlorine (molar ratio)=1:2.2 and 190～210℃.Then 2,6-dichloropyridine was hydrolyzed by base and converted into 6-chloro-2(1H)- pyridinol with 85% yield under pressure.The final product was confirmed by elemental analysis,IR, ~1H NMR and MS.The results showed that the synthetic method was quite reliable. |
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| Keywords: | pyridine photochlorination 2 6-dichloropyridine 6-chloro-2(lH)-pyridinol |
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