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Cobalt‐Catalysed Addition of Allylidene Dipivalate to Aldehydes. A Formal Homoaldol Condensation |
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| Authors: | Marco Lombardo Sebastiano Licciulli Filippo Pasi Gaetano Angelici Claudio Trombini |
| Abstract: | A Co(I)‐catalysed condensation of allylidene dipivalate with aldehydes to give (Z)‐4‐hydroxybut‐1‐enyl pivalates in 62 to 87% isolated yields, is reported. Reactions are run in acetonitrile at 0 or 25 °C depending on the nature of the aldehyde, and exploiting the Co(II)/Zn(0) redox couple for the preparation of the catalytic Co(I) species. |
| Keywords: | Allylidene dipivalate catalysis cobalt(I) homoaldol reaction γ ‐hydroxy carbonyl compounds regioselectivity |