Controlling ion release from bioactive glass foam scaffolds with antibacterial properties |
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Authors: | Julian R Jones Lisa M Ehrenfried Priya Saravanapavan Larry L Hench |
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Affiliation: | (1) Department of Materials, Imperial College London, South Kensington Campus, London, SW7 2AZ;(2) Cambridge Centre for Medical Materials, Department of Materials Science and Metallurgy, University of Cambridge, Pembroke Street, Cambridge, CB2 3QZ, U.K. |
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Abstract: | Bioactive glass scaffolds have been produced, which meet many of the criteria for an ideal scaffold for bone tissue engineering
applications, by foaming sol-gel derived bioactive glasses. The scaffolds have a hierarchical pore structure that is very
similar to that of cancellous bone. The degradation products of bioactive glasses have been found to stimulate the genes in
osteoblasts. This effect has been found to be dose dependent. The addition of silver ions to bioactive glasses has also been
investigated to produce glasses with bactericidal properties. This paper discusses how changes in the hierarchical pore structure
affect the dissolution of the glass and therefore its bioactivity and rate of ion delivery and demonstrates that silver containing
bioactive glass foam scaffolds can be synthesised. It was found that the rate of release of Si and Ca ions was more rapid
for pore structures with a larger modal pore diameter, although the effect of tailoring the textural porosity on the rate
of ion release was more pronounced. Bioactive glass scaffolds, containing 2 mol% silver, released silver ions at a rate that
was similar to that which has previously been found to be bactericidal but not high enough to be cytotoxic to bone cells. |
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