Localized surface plasmon resonance-based hybrid Au–Ag nanoparticles for detection of Staphylococcus aureus enterotoxin B |
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Authors: | Shaoli Zhu ChunLei Du Yongqi Fu |
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Affiliation: | aInstitute of Optics and Electronics, Chinese Academy of Sciences, Chengdu 610209, PR China;bSchool of Physical Electronics, University of Electronic Science and Technology of China, Chengdu 610054, Sichuan Province, PR China;cSchool of Electronic and Electrical Engineering, Nanyang Technological University, Singapore 639798, Singapore |
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Abstract: | A triangular hybrid Au–Ag nanoparticles array was proposed for the purpose of biosensing in this paper. Constructing the hybrid nanoparticles, an Au thin film is capped on the Ag nanoparticles which are attached on glass substrate. The hybrid nanoparticles array was designed by means of finite-difference and time-domain (FDTD) algorithm-based computational numerical calculation and optimization. Sensitivity of refractive index of the hybrid nanoparticles array was obtained by the computational calculation and experimental detection. Moreover, the hybrid nanoparticles array can prevent oxidation of the pure Ag nanoparticles from atmosphere environment because the Au protective layer was deposited on top of the Ag nanoparticles so as to isolate the Ag particles from the atmosphere. We presented a novel surface covalent link method between the localized surface plasmon resonance (LSPR) effect-based biosensors with hybrid nanoparticles array and the detected target molecules. The generated surface plasmon wave from the array carries the biological interaction message into the corresponding spectra. Staphylococcus aureus enterotoxin B (SEB), a small protein toxin was directly detected at nanogramme per milliliter level using the triangular hybrid Au–Ag nanoparticles. Hence one more option for the SEB detection is provided by this way. |
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Keywords: | Hybrid Au– Ag nanoparticles Nano-biosensor LSPR Spectroscopy |
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