The development of adaptive body reactions after intensive physical loading] |
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| Authors: | NI Varakina LV Mikha?lik SS Chabanenko SM Zubkova |
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| Affiliation: | Laboratory of Biochemistry, Institute of Toxicology, Russian Federation Ministry of Health, St. Petersburg, Russia. |
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| Abstract: | The dependence between the activity parameters of muscarine antagonists in the prevention of haloperidol catalepsy in rats and those in tests characterizing the interaction of ligands and various subtypes of m-cholinoceptors was studied. It was established by constructing the mathematical dependence that blockade of m1-cholinoceptors increases, while that of m2-cholinoceptors reduces the antiparkinsonian activity of the drugs. The activity of the muscarine antagonist pentiphan in the prevention of haloperidol-induced catalepsy in rats exceeds the activity of such traditional antiparkinsonian drugs as cyclodol and amedin. |
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