| 齐多夫定脱保护副产物的结构鉴定及其应用研究 |
| |
| 引用本文： | 朱建明. 齐多夫定脱保护副产物的结构鉴定及其应用研究[J]. 精细化工中间体, 2006, 36(4): 26-27 |
| |
| 作者姓名： | 朱建明 |
| |
| 作者单位： | 厦门迈克制药有限公司,福建,厦门,361022 |
| |
| 摘 要： | 采用FT-IR、MS、NMR等波谱技术对齐多夫定(AZT)脱保护副产物进行结构鉴定,确定了其结构为三苯甲基甲醚,并开发了其商业应用技术。在HCl作用下完成醚键断裂,把三苯甲基甲醚转化为三苯基氯甲烷,收率95.8%,该产物可再次应用到合成AZT的合成过程中,降低其生产成本。
|
| 关 键 词： | 三苯基氯甲烷 三苯甲基甲醚 副产物 结构 |
| 文章编号： | 1009-9212(2006)04-0026-02 |
| 收稿时间： | 2006-03-20 |
| 修稿时间： | 2006-03-20 |
The Structural Identification of the Byproduct from Zidovudine and it's Application |
| |
| ZHU Jian-ming. The Structural Identification of the Byproduct from Zidovudine and it's Application[J]. Fine Chemical Intermediates, 2006, 36(4): 26-27 |
| |
| Authors: | ZHU Jian-ming |
| |
| Affiliation: | Xiamen Mchem Laboratories LTD., Xiamen 361022, China |
| |
| Abstract: | A large number of byproduct was received in deprotection step of synthesis Zidovudine,the work for it's structural identification had been completed. The trityl methyl ether can react with hydrogen chloride and get the commercial chemical material trityl chloride with high yield. |
| |
| Keywords: | trityl chloride trityl methyl ether outgrowth structural identification |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
