Synthesis and characterization of biodegradable TPP/genipin co-crosslinked chitosan gel beads |
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Authors: | Fwu-Long MiHsing-Wen Sung Shin-Shing Shyu Chia-Ching SuChih-Kang Peng |
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Affiliation: | a Division of Applied Chemistry, Department of Applied Science, Chinese Naval Academy, 669 Jiun Shiaw Road, Kaohsiung 813, Taiwan ROC b Department of Chemical Engineering, National Tsing Hua University, Hsinchu 300, Taiwan ROC c Department of Chemical Engineering, Van Nung Institue of Technology, Chung-Li 320, Taiwan ROC d Department of Chemical and Material Engineering, National Central University, Chung-Li 312, Taiwan ROC |
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Abstract: | Novel chitosan gel beads were synthesized by a coupled ionic and chemical co-crosslinking mechanism. Tripolyphosphate (TPP) and a naturally occurring crosslinking reagent, genipin, which has been used in herbal medicine, were employed, respectively, as an ionic and a chemical crosslinkers to prepare the chitosan-based networks of gel beads. The competitive crosslinking of chitosan with ionic crosslinker (TPP) and chemical crosslinker (genipin) was characterized by FTIR, UV and EDAX spectroscopy (X-ray energy dispersion) spectroscopy. The variation of characteristic peak of genipin observed from UV spectroscopy and the characteristic peak of tripolyphosphate in crosslinked chitosan-based networks observed from FTIR spectroscopy suggests that the co-crosslinking mechanism is dependent on the pH of TPP/genipin co-crosslinker. The energy profiles of carbon and phosphorus estimated from confirms that chemical crosslinking dominates the co-crosslinking reaction at higher pH condition (pH 7.0 and 9.0) and ionic crosslinking dominates the co-crosslinking reaction at lower pH condition (pH 1.0, 3.0 and 5.0). The pH-dependent ionic/chemical co-crosslinking mechanism shows an obvious effect on the swelling property and enzymatic degradation behavior of prepared chitosan networks. These results reveal that the ionic/chemical co-crosslinked chitosan networks may be suitable for biomedical applications. |
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Keywords: | Chitosan Tripolyphosphate Genipin |
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