| 4-羟基-5-嘧啶甲酸乙酯衍生物的合成 |
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| 引用本文： | 黄统辉,张爱东,邓灵福,涂海洋.4-羟基-5-嘧啶甲酸乙酯衍生物的合成[J].化学试剂,2009,31(7). |
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| 作者姓名： | 黄统辉 张爱东 邓灵福 涂海洋 |
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| 作者单位： | 华中师范大学,农药与化学生物学教育部重点实验室,湖北,武汉,430079 |
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| 摘 要： | 由乙氧甲叉基丙二酸二乙酯和相应的脒在碱性条件下合成了4-羟基-5-嘧啶甲酸乙酯和2-甲基-4-羟基-5-嘧啶甲酸乙酯,原料易得、操作步骤简单、反应条件温和,产率呵分别达到80%和91%.
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| 关 键 词： | 甲叉基丙二酸二乙酯 4-羟基-5-嘧啶甲酸乙酯 合成 |
Synthesis of ethyl 4-hydroxypyrimidine-5-carboxylate derivatives |
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| HUANG Tong-hui,ZHANG Ai-dong,DENG Lingf-u,TU Hai-yang.Synthesis of ethyl 4-hydroxypyrimidine-5-carboxylate derivatives[J].Chemical Reagents,2009,31(7). |
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| Authors: | HUANG Tong-hui ZHANG Ai-dong DENG Lingf-u TU Hai-yang |
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| Affiliation: | Key Laboratory of Pesticide & Chemical Biology of Ministry of Education;Central China Normal University;Wuhan 430079;China |
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| Abstract: | Starting from diethyl 2-(ethoxymethylene)malonate,the target molecules ethyl 4-hydroxypyrimidine-5-carboxylate and ethyl 4-hydroxy-2-methylpyrimidine-5-carboxylate were synthesized at a yield of 80% and 92%,respectively.The one-step method for synthesis of the target molecules was simple with a higher yield of target products as compared to the reported method. |
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