Optimization of the freeze-drying process for microemulsion systems |
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| Authors: | Andreza Rochelle do Vale Morais Morais Francisco Humberto Xavier-Jr. Éverton do Nascimento Alencar Christian Melo de Oliveira Nednaldo Dantas Santos Arnóbio Antônio Silva-Júnior |
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| Affiliation: | 1. Programa de Pós-gradua??o em Nanotecnologia Farmacêutica, Universidade Federal do Rio Grande do Norte (UFRN), Natal, Rio Grande do Norte, Brazil;2. Institut Gallien Paris-Sud, UMR-CNRS 8612, Université Paris-Sud, Chatenay-Malabry, France;3. Programa de Pós-gradua??o em Ciências da Saúde, UFRN, Natal, Rio Grande do Norte, Brazil;4. Institut Gallien Paris-Sud, UMR-CNRS 8612, Université Paris-Sud, Chatenay-Malabry, France;5. Programa de Pós-gradua??o em Ciências da Saúde, UFRN, Natal, Rio Grande do Norte, Brazil;6. Departamento de Farmácia, UFRN, Laboratório de Tecnologia e Biotecnologia Farmacêutica, Natal, Rio Grande do Norte, Brazil |
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| Abstract: | AbstractThe aim of this work was to develop a freeze-dried microemulsion using Design of Experiment and loaded with Amphotericin B, which is quite unstable in aqueous media, as a drug model. Different types of cryoprotectants were studied. The microemulsion containing maltose at 5% (w/w), frozen at a temperature of –80?°C and performed with a 24?h of freeze-drying time, yielded the best results. The freeze-drying process reduced the microemulsion droplet size and does not change the AmB content. Therefore, microemulsions containing maltose are suitable for drug incorporation, and the freeze-drying was able to enhance the drug stability in the system. |
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| Keywords: | Amphotericin B statistical experimental design lyophilization dispersed system |
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