| 模拟移动床色谱分离体系模式与关键因子的计算机模拟研究 |
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| 引用本文： | 蔡宇杰,丁彦蕊,张大兵,石贵阳,彭奇均,须文波. 模拟移动床色谱分离体系模式与关键因子的计算机模拟研究[J]. 计算机与应用化学, 2005, 22(12): 1146-1148 |
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| 作者姓名： | 蔡宇杰 丁彦蕊 张大兵 石贵阳 彭奇均 须文波 |
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| 作者单位： | 江南大学生物工程学院工业生物技术教育部重点实验室,江苏,无锡,2140036;江南大学信息工程学院,江苏,无锡,214036;江苏汉邦科技有限公司,江苏,淮安,223001;江南大学化学与材料工程学院,江苏,无锡,214036 |
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| 摘 要： | 采用浮点编码遗传算法对模拟移动床色谱的分离系统模式进行了设计，并研究了，分离过程中传质和扩散对分离效果的影响。结果表明模拟移动床色谱中区2和区3的色谱柱的数目对提高生产强度起决定性的作用，而区1和区4的影响较小。同时改善分离过程中的传质与扩散可提高生产强度，在分离过程中传质所起的影响比扩散大得多。
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| 关 键 词： | 模拟移动床色谱 浮点编码遗传算法 色谱柱数目 传质 扩散 |
| 文章编号： | 1001-4160（2005）12-1146-1148 |
| 收稿时间： | 2005-01-08 |
| 修稿时间： | 2005-01-082005-08-25 |
Research on separation model and key factors of SMB chromatography with computer simulation |
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| CAI YuJie,DING YanRui,ZHANG DaBing,SHI GuiYang,PENG QiJun,XU WenBo. Research on separation model and key factors of SMB chromatography with computer simulation[J]. Computers and Applied Chemistry, 2005, 22(12): 1146-1148 |
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| Authors: | CAI YuJie DING YanRui ZHANG DaBing SHI GuiYang PENG QiJun XU WenBo |
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| Abstract: | The real coded genetic algorithm was used to design the structure of simulated moving bed chromatography. In addition the effect of mass transfer and diffusion was studied. The result show that the zone I and zone IE were very important to the separation of SMB chromatography and the effect of zone I and Zone IV were less. The productivity would be improved by controlling the mass transfer condition and diffusion. It also was found that the effect of diffusion was less than mass transfer. |
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| Keywords: | simulated moving bed chromatography, real coded genetic algorithmm, chromatography column numbers mass transfer diffusion |
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