Porcine hemoglobin promotes lipid excretion to feces more strongly than globin protein in rats |
| |
| Authors: | Hosomi Ryota Otsuka Ren Arai Hirofumi Kanda Seiji Nishiyama Toshimasa Yoshida Munehiro Fukunaga Kenji |
| |
| Affiliation: | 1.Laboratory of Food and Nutritional Sciences, Faculty of Chemistry, Materials, and Bioengineering,Kansai University,Osaka,Japan;2.Department of Biotechnology and Environmental Chemistry,Kitami Institute of Technology,Kitami, Hokkaido,Japan;3.Department of Public Health,Kansai Medical University,Osaka,Japan |
| |
| Abstract: | In an effort to clarify whether the lipid-lowering effect of hemoglobin is due to globin protein or heme, this study investigated the effects of dietary porcine hemoglobin (PH) and porcine globin (PG) on lipids contents of serum, liver, and feces in rats. Five-week-old male Wistar rats were divided into 3 dietary groups of 7 rats each, with one group receiving a control diet and the other groups receiving diets containing 1.25% (w/w) PH or 1.18% (w/w) PG for 4 weeks. The PH diet decreased triacylglycerol content in serum and cholesterol in serum and liver, whereas the PG diet reduced triacylglycerol content in serum and cholesterol in liver. Fecal lipid excretion in the PH group was significantly higher than in the PG group. Therefore, PH affected lipid excretion to feces due to globin protein as well as heme. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
