Topology optimization of three dimensional tissue engineering scaffold architectures for prescribed bulk modulus and diffusivity |
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Authors: | Heesuk Kang Chia-Ying Lin Scott J Hollister |
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Affiliation: | (1) Department of Mechanical Engineering, University of Michigan, Ann Arbor, MI, USA;(2) Spine Research Laboratory, Department of Neurosurgery, University of Michigan, Ann Arbor, MI, USA;(3) Scaffold Tissue Engineering Group, Department of Biomedical Engineering, Mechanical Engineering, and Surgery, University of Michigan, 2208 Lurie Biomedical Engineering Building, 1101 Beal Ave, Ann Arbor, MI 48109, USA |
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Abstract: | Tissue engineering scaffolds play critical roles in skeletal tissue regeneration by supporting physiological loads as well
as enhancing cell/tissue migration and formation. These roles can be fulfilled by the functional design of scaffold pore architectures
such that the scaffold provides proper mechanical and mass transport environments for new tissue formation. These roles require
simultaneous design of mechanical and mass transport properties. In this paper, a numerical homogenization based topology
optimization scheme was applied to the design of three dimensional unit microstructures for tissue engineering scaffolds.
As measures of mechanical and mass transport environments, target effective bulk modulus and isotropic diffusivity were achieved
by optimal design of porous microstructure. Cross property bounds between bulk modulus and diffusivity were adapted to determine
feasible design targets for a given porosity. Results demonstrate that designed microstructures could reach cross property
bounds for porosity ranging from 30% to 60%. |
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