| 99Tcm标记苯托品类多巴胺转运蛋白显像剂的制备和小鼠体内分布 |
| |
| 引用本文： | 张春艳,贾红梅,贾芳,刘伯里.99Tcm标记苯托品类多巴胺转运蛋白显像剂的制备和小鼠体内分布[J].核化学与放射化学,2002,24(4):232-235. |
| |
| 作者姓名： | 张春艳 贾红梅 贾芳 刘伯里 |
| |
| 作者单位： | 北京师范大学,化学系,北京,100875 |
| |
| 基金项目： | 北京师范大学青年基金资助项目 ( 2 72 0 0 7) |
| |
| 摘 要： | 合成了以苯托品（Benztropine)为前体的含巯基的单齿化合物,其光谱数据和结构相符。使用配体交换法与3－硫杂－1,5－戊二硫醇（SSS）配位合成了^99Tc^m的“3＋1”型混配螯合物a。螯合物a在小鼠脑中有一定的初始摄取和滞留量,在t=5min时,ID＝1.03%／g;对纹状体也有一定的亲和力,纹状体和小脑摄取比值随时间延长而增加,在t=60min时,R（纹状体／小脑）＝1.3。混配螯合物有成为多巴胺转运蛋白显像剂的可能。
|
| 关 键 词： | 标记 多巴胺转运蛋白显像剂 苯托品 生物分布 纹状体 放射性药物 锝99 |
| 文章编号： | 0253-9950(2002)04-0232-04 |
| 修稿时间： | 2002年1月25日 |
SYNTHESIS, LABELING AND BIODISTRIBUTION OF TECHNETIUM-99-LABELED BENZTROPINE ANALOGS AS DOPAMINE TRANSPORTER IMAGING AGENTS |
| |
| ZHANG Chun-yan,JIA Hong-mei,JIA Fang,LIU Bo-li.SYNTHESIS, LABELING AND BIODISTRIBUTION OF TECHNETIUM-99-LABELED BENZTROPINE ANALOGS AS DOPAMINE TRANSPORTER IMAGING AGENTS[J].Journal of Nuclear and Radiochemistry,2002,24(4):232-235. |
| |
| Authors: | ZHANG Chun-yan JIA Hong-mei JIA Fang LIU Bo-li |
| |
| Affiliation: | ZHANG Chun-yan,JIA Hong-mei,JIA Fang,LIU Bo-liDepartment of Chemistry,Beijing Normal University,Beijing 100875,China |
| |
| Abstract: | In developing 99Tc m-labelled dopamine transporter imaging agents, a new substituted compound is designed and synthesized. By tetering S 3 chelate system onto it, one technetium "3+1" complex is formed. Biodistribution studies are carried out in mice. The results demonstrate that the labeled compound(a) has the ability to penetrate the intergrate blood brain barrier(1.03 %/g), at 5 min, post injection and retains for a certain time in brain. The ST/CB is 1.3 at 60 min after iv injection in mice. It also shows that brain uptake and selectivity of labeled compound(a) are higher and further improving is needed. |
| |
| Keywords: | dopaimine transporter 99Tc m benztropine biodistribution |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
| 点击此处可从《核化学与放射化学》浏览原始摘要信息 |
|
点击此处可从《核化学与放射化学》下载全文 |
|
