| 液态发酵法产Lovastatin的研究进展 |
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| 引用本文： | 宋红平,李梅,冯琳,安晓娟,李师翁. 液态发酵法产Lovastatin的研究进展[J]. 食品与发酵工业, 2011, 37(8) |
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| 作者姓名： | 宋红平 李梅 冯琳 安晓娟 李师翁 |
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| 作者单位： | 兰州交通大学化学与生物工程学院,甘肃兰州,730070 |
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| 基金项目： | 国家自然科学基金项目(No.30960063) |
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| 摘 要： | Lovastatin是Aspergillus和Monascus等丝状真菌的次生代谢产物,在人体内通过竞争性地抑制胆固醇合成的限速酶3-羟-3-甲基戊二酰辅酶A还原酶而阻断内源性胆固醇的合成,强烈降低血胆固醇浓度,是预防和治疗高血脂症和高胆固醇症及相关病症的有效药物。近年来,研究人员对液态发酵产Lovastatin开展了广泛深入的研究,取得了一系列重要研究进展,促进了工业化生产Lovastatin的发展。文中对Lovastatin高产菌种及选育、碳源和氮源及发酵培养条件对不同菌种产Lovastatin的影响等方面的研究进展进行了综述,为相关的研究与应用提供参考。
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| 关 键 词： | Lovastatin 红曲霉 土曲霉 研究进展 |
The Research Progresses on the Production of Lovastatin by the Liquid Fermentation |
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| Song Hong-ping,Li Mei,Feng Lin,An Xiao-juan,Li Shi-weng. The Research Progresses on the Production of Lovastatin by the Liquid Fermentation[J]. Food and Fermentation Industries, 2011, 37(8) |
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| Authors: | Song Hong-ping Li Mei Feng Lin An Xiao-juan Li Shi-weng |
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| Affiliation: | Song Hong-ping,Li Mei,Feng Lin,An Xiao-juan,Li Shi-weng(School of Chemical and Biological Engineering,Lanzhou Jiaotong University,Lanzhou 730070,China) |
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| Abstract: | Lovastatin is a secondary metabolite produced by filamentous fungi,such as Aspergillus terreus and Monascus sp.Lovastatin competitively inhibits 3-hydroxy-3-methylglutaryl CoA(HMG-CoA) reductase,the rate-limiting enzyme in cholesterol biosynthesis and lower plasma cholesterol level,particularly lower low density lipoprotein level in human.Lovastatin can reduce the risk for coronary artery disease morbidity and has emerged as a preventive drug for hypercholesterolemia and cardiovascular disease.Recently,many... |
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| Keywords: | Lovastatin Monascus Aspergillus research progress |
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