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| 超高效液相色谱-串联质谱法同时测定鱼、肉类罐头食品中的BADGE、NOGE及其衍生物 | |
| 引用本文： | 林赛君,陈思,薛鸣,张虹.超高效液相色谱-串联质谱法同时测定鱼、肉类罐头食品中的BADGE、NOGE及其衍生物[J].食品与发酵工业,2011,37(8). |
| 作者姓名： | 林赛君 陈思 薛鸣 张虹 |
| 作者单位： | 1. 杭州市质量技术监督检测院,浙江杭州,310014 2. 浙江工商大学食品与生物工程学院,浙江杭州,310035 3. 杭州市疾病预防控制中心,浙江杭州,310021 |
| 基金项目： | 浙江省科技厅项目(2010C32G2050021)资助; 浙江省自然科学基金项目(Y3100689)资助; 浙江省质量技术监督系统科研计划项目(20100221)资助 |
| 摘 要： | 建立了一种罐头食品中的BADGE(bisphenol A diglycidyl ether,双酚A-二环氧甘油醚)、NOGE(novolacglycidyl ether,酚醛清漆甘油醚)及其衍生物含量的超高效液相色谱-串联质谱检测法。前处理包括正己烷/丙酮微波辅助萃取,Varain-PS-DVB固相萃取柱净化等。样品经BEH C18色谱柱(100 mm×2.1 mm,1.7μm)分离,以乙腈和0.2%甲酸水为流动相,进行梯度洗脱,在API 4000-QTRAP质谱仪电喷雾正离子、多反应监测(MRM)模式下进行检测。分析物检出限达到0.010 2 ng/g到0.197 2 ng/g,三水平加标回收率在65.7%～99.1%。 |
| 关 键 词： | 超高效液相色谱-串联质谱法 罐头食品 BADGE NOGE 衍生物 检测 |
Determination of Bisphenol a Diglycidyl Ether(BADGE),Novolac Glycidyl Ethers(NOGE) and Its Derivatives in Canned Fish and Meat by Ultra-performance Liquid Chromatography with Tandem Mass Spectrometry |
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| Lin Sai-jun,Chen Si,Xue Ming,Zhang Hong.Determination of Bisphenol a Diglycidyl Ether(BADGE),Novolac Glycidyl Ethers(NOGE) and Its Derivatives in Canned Fish and Meat by Ultra-performance Liquid Chromatography with Tandem Mass Spectrometry[J].Food and Fermentation Industries,2011,37(8). | |
| Authors: | Lin Sai-jun Chen Si Xue Ming Zhang Hong |
| Affiliation: | Lin Sai-jun1,Chen Si2,Xue Ming3,Zhang Hong2 1(Hangzhou Institute of Test and Calibration for Quality and Technology Supervision,Hangzhou 310014,China) 2(School of Food Science and Biotechnology Engineering,Zhejiang Gongshang University,Hangzhou 310035,China) 3(Hangzhou Center for Disease Control and Prevention,Hangzhou 310021,China) |
| Abstract: | An ultra-performance liquid chromatography with tandem mass spectrometry method for determination of bisphenol A diglycidyl ether(BADGE),novolac glycidyl ether(NOGE) and its derivatives from canned food has been developed.The proposed method includes microwave-assisted extraction followed by puri?cation by solid phase extraction(SPE).After separation by BEH C18(column 100 mm×2.1 mm,1.7 μm),the sample was detected by API 4000-QTRAP mass spectrometry under positive electrospray ionization mode,with acetonitrile and 0.2% aqueous formic acid as mobile phase.The detection limits were 0.010 2~0.197 2 ng/g,and recoveries at three different concentrations ranged from 65.7% to 99.1%.This method was successfully applied to canned fish and meat,the highest total contents of 3~6 R-NOGE reached 209.03 mg/6 dm2. |
| Keywords: | ultra-performance liquid chromatography-tandem mass spectrometry canned food bisphenol A diglycidyl ether(BADGE) novolac glycidyl ethers(NOGE) derivatives determination |
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