Prevention of allogeneic fetal rejection by tryptophan catabolism |
| |
| Authors: | DH Munn M Zhou JT Attwood I Bondarev SJ Conway B Marshall C Brown AL Mellor |
| |
| Affiliation: | Program in Molecular Immunology, Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA 30912, USA. |
| |
| Abstract: | In 1953 Medawar pointed out that survival of the genetically disparate (allogeneic) mammalian conceptus contradicts the laws of tissue transplantation. Rapid T cell-induced rejection of all allogeneic concepti occurred when pregnant mice were treated with a pharmacologic inhibitor of indoleamine 2,3-dioxygenase (IDO), a tryptophan-catabolizing enzyme expressed by trophoblasts and macrophages. Thus, by catabolizing tryptophan, the mammalian conceptus suppresses T cell activity and defends itself against rejection. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
