| Ullmann法合成氧杂蒽酮的研究 |
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| 引用本文： | 王纪元,孙学军,王明清,马运磊,李朋涛,尤进茂. Ullmann法合成氧杂蒽酮的研究[J]. 化学世界, 2009, 50(7) |
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| 作者姓名： | 王纪元 孙学军 王明清 马运磊 李朋涛 尤进茂 |
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| 作者单位： | 1. 曲阜师范大学化学与化工学院,山东,曲阜,273165
2. 曲阜师范大学化学与化工学院,山东,曲阜,273165;中国科学院西北高原生物研究所,青海,西宁,810001 |
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| 摘 要： | 以2-氯苯甲酸和苯酚为原料,先经过Ullmann缩合反应制得2-苯氧基苯甲酸,再在三氯氧磷作用下脱水环合得到氧杂蒽酮。合成中间体产物的最佳条件是:n(2-氯苯甲酸)∶n(苯酚)∶n(碳酸钾)∶n(氧化铜)为1∶6∶1.5∶0.06。该方法具有操作简便、条件温和、环境友好等优点,氧杂蒽酮总产率有63.84%。
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| 关 键 词： | 2-氯苯甲酸 Ullmann缩合反应 2-苯氧基苯甲酸 氧杂蒽酮 |
Synthesis of Xanthone by Approach of Ullmann |
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| WANG Ji-yuan,SUN Xue-jun,WANG Ming-qing,MA Yun-lei,LI Peng-tao,YOU Jin-mao. Synthesis of Xanthone by Approach of Ullmann[J]. Chemical World, 2009, 50(7) |
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| Authors: | WANG Ji-yuan SUN Xue-jun WANG Ming-qing MA Yun-lei LI Peng-tao YOU Jin-mao |
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| Affiliation: | 1.School of Chemistry and Chemichal Engineering;Qufu Normal University;Shandong Qufu 273165;China;2.Northwest Plateau Institute of Biology;Chinese Academy of Sciences;Qinghai Xining 810001;China |
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| Abstract: | Xanthone was prepared by the Ullmann condensation of 2-chlorobenzoic acid and phenol followed by dehydration ring closure in the presence of phosphorus oxychloride. The optimum reaction conditions for the intermediate product were as follows.the reaction time of 2 h and n(2-chlorobenzoic acid) : n(phenol):n(potassium carbonate) : n(cupric oxide) = 1 : 6 : 1.5 : 0. 06. The reactions were run under mild conditions and they were environmentally friendly. The overall yeild of xanthone was 63.84 %. |
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| Keywords: | 2-chlorobenzoic acid Ullmann condensation 2-phenoxybenzoic acid xanthone |
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