| LC/MS技术在发现和鉴定药物中有关物质的应用 |
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| 引用本文： | 王鹏远,张金兰.LC/MS技术在发现和鉴定药物中有关物质的应用[J].质谱学报,2010,31(6):362-367. |
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| 作者姓名： | 王鹏远 张金兰 |
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| 作者单位： | 中国医学科学院&北京协和医学院，药物研究所，北京100050 |
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| 摘 要： | 论述了LC/MS技术在发现和鉴定药物中有关物质的应用特点,比较和讨论不同原理质量分析器在药物杂质鉴定中的适用范围和优缺点,并总结了近几年LC/MS技术在药物有关物质分析中的应用实例。
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| 关 键 词： | 液相色谱-质谱（LC/MS） 四极杆质谱 飞行时间质谱 离子阱质谱 杂质鉴定 |
Applications of LC/MS in Discovery and Characterization of Related Impurities in Drug |
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| WANG Peng-yuan,ZHANG Jin-lan.Applications of LC/MS in Discovery and Characterization of Related Impurities in Drug[J].Journal of Chinese Mass Spectrometry Society,2010,31(6):362-367. |
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| Authors: | WANG Peng-yuan ZHANG Jin-lan |
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| Affiliation: | Institute of Materia Medical, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China |
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| Abstract: | Application characteristics and research ideas of liquid chromatography-mass spectrometry (LC/MS) techniques in discovery and characterization of related impurities of durg were reviewed. The scope of application and strong and weak points of different mass analyzers used in characterization of drug related impurities were compared and discussed. The application samples of analysis in drug related impurities by LC/MS techniques were summarized in recent years. |
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| Keywords: | liquidchromatography-massspectrometry(LC/MS) quadrupolemassspectrometry time-of-flightmassspectrometry iontrapmassspectrometry impuritystructurecharacterization |
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