Detection of multiple disease indicators by an autonomous biomolecular computer |
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Authors: | Gil Binyamin Kahan-Hanum Maya Skirtenko Natalia Adar Rivka Shapiro Ehud |
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Affiliation: | Department of Biological Chemistry, Weizmann Institute of Science, Rehovot 76100, Israel. |
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Abstract: | The promise of biomolecular computers is their ability to interact with naturally occurring biomolecules, enabling in the future the development of context-dependent programmable drugs. Here we show a context-sensing mechanism of a biomolecular automaton that can simultaneously sense different types of molecules, allowing future integration of biomedical knowledge on a broad range of molecular disease symptoms in the decision of a biomolecular computer to release a drug molecule. |
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