尿道炎后慢性前列腺炎病原学初探

目的探讨尿道炎后慢性前列腺炎的病原体分布情况。方法对208例尿道炎后慢性前列腺炎患者的尿和前列腺液行Meares-Stamey分段法培养。对其培养和药物敏感试验结果进行统计分析。结果 208例患者中共检出病原体173株,其中细菌128株,Uu 36株、Mh 7株、Ct 2株;混合感染28例（13.46%）;淋球菌、念珠菌、滴虫检测均为阴性;细菌中葡萄球菌属为102株,以凝固酶阴性葡萄球菌最为常见。针对葡萄球菌药物敏感试验结果显示其对临床常用的多种抗生素耐药,而对万古霉素、利福平、氯林可霉素、庆大霉素、复方新诺明等耐药率相对较低。结论凝固酶阴性葡萄球菌是尿道炎后慢性前列腺炎的主要病原菌,衣原体和支原体在其发病中也起到一定作用。针对性的病原体检查和药敏试验对临床诊断和治疗具有重要作用。

Etiology of Post-Urethritis Chronic Prostatitis

Objective To investigate the distribution of pathogens causing post-urethritis chronic prostatitis（PUCP）.Methods Urine and prostatic secretions（EPS） were collected and cultured according to Meares and Stamey fractionation methods in 208 patients with PUCP.The results of culture and drug sensitive tests were analyzed.Results In 208 patients,173 pathogens were found,including 128 bacteria,36 Ureaplasma urialyticum（Uu）,7 Mycoplasma hominis（Mh） and 2 Chlamydia trachomatis（Ct）.There were 28 patients（13.46%）suffering from mixed infection.No Neisseria gonorrhoeae（Ng）,Monilia and Infusorian were detected.There were 102 Staphylococci in 128 bacteria,and the most dominant staph were coagulas-negative staphylococcus.The drug sensitive tests showed that the staph were highly resistant to usual antibiotics,but they were relatively sensitive to vancomycin,rifampin,clindamycin,gentamicin and trimethoprim-sulfamethoxazole.Conclusion Coagulas-negative staphylococcus were the main pathogenic bacteria of PUCP,In addition,Ct and mycoplasma play some roles in PUCP.The isolation and drug sensitive test of pathogens play important roles in diagnosis and treatment of PUCP.