重症颅脑外伤应用纳洛酮的临床观察

目的探讨纳洛酮在重症颅脑外伤中的应用效果及其机制。方法选择GCS评分为3~8分重症颅脑外伤患者38例作为治疗组在常规治疗基础上加用纳洛酮治疗,另以相同情况的重症颅脑外伤39例作为对照组给予常规治疗。观察意识变化、生命体征、远期疗效。结果治疗组意识改善及远期恢复良好率明显高于对照组,呼吸机者使用时间及住院时间缩短,重残及死亡率明显减少（P〈0.05）。2组比较差异有统计学意义。结论纳洛酮能有效促醒、明显降低重症颅脑外伤患者的死亡率、改善预后等。

Clinical Study of Naloxone in Use of Severe Brain Injuries

Objective To discuss the clinical effects and therapeutic mechanism of naloxone in patients with acute severe brain injury.Methods Seventy-seven patients with severe brain injury（GCS 3~8） received either naxolone（trial group,n=38） or routine treatment（control group,n=39）.The changes in consciousness and vital signs of patients were observed and the long-term therapeutic effects were evaluated.Results Compared with the control group,the level of consciousness was improved by naxolone.Moreover,the good rate of long-term recovery was increased,the time requiring respirator treatment and length of hospital stay were shortened,and the disability rate and mortality rate were reduced（P〈0.05）.Conclusion Naloxone can accelerate recovery from coma and reduce mortality in patients with acute severe brain injury.