Zinc deficiency increases the rate of Δ6 desaturation of linoleic acid in rat mammary tissue |
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| Authors: | S C Cunnane K W J Wahle |
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| Affiliation: | (1) The Rowett Research Institute, AB2 9SB Aberdeen, UK;(2) Present address: Nuffield Laboratories of Comparative Medicine, The Institute of Zoology, The Zoological Society of London, Regent's Park, NW1 4RY London, UK |
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| Abstract: | The effect of zinc deficiency on the Δ6-desaturation of 1-14C] linoleic acid was studied in mammary tissue microsomes from lactating rats. The rats were maintained on zinc-adequate (20
ppm zinc) or zinc-deficient (10 ppm zinc changing to 0.5 ppm zinc during last trimester) diets throughout gestation and for
the first 3 days of lactation. Mammary tissue microsomes were incubated with 1-14C] linoleic acid and other samples of mammary tissue, mammary milk and the milk in the stomachs of the pups were analyzed
for total fatty acid composition. In mammary microsomes from zinc-deficient rats, Δ6-desaturation of linoleic acid was 3.4 times greater than in microsomes from zinc-adequate rats. This change in metabolism
of linoleic acid was reflected by comparable changes in the relative tissue and milk composition of linoleic and arachidonic
acids and in the ratios of palmitic to palmitoleic acid, stearic to oleic acid and linoleic and arachidonic acid. |
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