^90Y—树脂用于放射杀伤的实验研究

用Ｄｏｗｅｘ５０树脂吸附＾９０Ｓｒ－＾９０Ｙ平衡体制成＾９０Ｙ发生器，用柠檬酸钠缓冲液淋洗得到＾９０Ｙ，在ｐＨ≥８．０时，＾９０Ｙ与Ｂｉｏ－Ｒｅｘ７０树脂结合４ｈ，结合率达９０％以上，＾９０Ｙ标记树脂经动脉导管选择性地注入狗的右下肝叶，给药后＾９０Ｙ的总量药总剂量的１％，两周后Ｘ－ＣＴ或像显示，给药肝地呈液化性坏死，大体标叶观察见药肝叶萎缩，病理检查见肝细胞成片死亡，结果表明，＾９０Ｙ标记树脂是一

Experimental study on the radioinjury action of (90)~Y labelled resin

90Y generator was made by absorption 90Sr-90Y equilibrium system to Dowex 50 resin. 90Y was obtained by elution with sodium citrate buffer solution. The 90Y was mixed with Biou-Rex 70 resin, high binding rate were achieved when the pH value was more than eight and the mixing duration was 4 h.90Y labelled resin was injected through hepatic artery catheter into the right lower lobe of liver in dog. The total blood concentration of 90Y was estimated to be 1% of total dose administered.After 2 weeks, X-CT showed that the administered liver lobe observed liquified necrosis and liver atrophy grossly, also liver cell die away extensive1y in pathological sections.These prelimenary findings suggested that with selective administration of hepatic artery catheterization, radiolabelled resin was an effective and safe radioinjury reagent, and can be used for tumor radiotherapy.