| L-苯丙氨酸甲酯消旋反应改进 |
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| 引用本文： | 刘毅,张玲,缑灵山,孙强,陈美林.L-苯丙氨酸甲酯消旋反应改进[J].云南化工,2008,35(6). |
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| 作者姓名： | 刘毅 张玲 缑灵山 孙强 陈美林 |
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| 作者单位： | 徐州医学院药学系,江苏,徐州,221004 |
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| 基金项目： | 江苏省高校自然科学基金
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徐州医学院院长专项人才基金
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| 摘 要： | 对L-苯丙氨酸甲酯消旋方法进行改进。研究了L-苯丙氨酸甲酯在不同催化剂、催化剂用量、反应时间下的消旋制备DL-苯丙氨酸甲酯过程。结果表明:当以水杨醛为催化剂、强酸性D072离子交换树脂为助催化剂、n(水杨醛)∶n(L-苯丙氨酸甲酯)=0.1回流反应时,消旋效果最好。
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| 关 键 词： | DL-苯丙氨酸甲酯 消旋 D-苯丙氨酸 水杨醛 |
Improvement on the Racemization of L-Phenylalanine Methyl Ester |
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| LIU Yi,ZHANG Ling,GOU Ling-shan,SUN Qiang,CHEN Mei-lin.Improvement on the Racemization of L-Phenylalanine Methyl Ester[J].Yunnan Chemical Technology,2008,35(6). |
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| Authors: | LIU Yi ZHANG Ling GOU Ling-shan SUN Qiang CHEN Mei-lin |
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| Affiliation: | Department of Pharmacy;Xuzhou Medical College;Xuzhou 221004 |
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| Abstract: | Racemization of L-phenylalanine methyl ester was improved,and effect of catalyst,catalyst dosage and reaction time was studied.Result indicated that the optimal condition was molar ratio of salicylaldehyde to L-phenylalanine methyl ester of 0.1,with 0.1 molar of D072 ion-exchange resin as catalyst and refluxing the mixture. |
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| Keywords: | DL-phenylalanine methyl ester racemization D-phenylalanine salicylaldehyde |
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