| Rhenium labeled McAb—SZ39 and colloid |
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| 引用本文： | ZUJianhua DONGMo 等.Rhenium labeled McAb—SZ39 and colloid[J].核技术(英文版),1999,10(4):197-202. |
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| 作者姓名： | ZUJianhua DONGMo |
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| 作者单位： | [1]ShanghaiInstituteofNuclearResearch,theChineseAcademyofSciences,Shanghai201800 [2]ShanghaiInstituteofNucl,theChineseAcademyofSciences,Shanghai201800 |
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| 摘 要： | Two kinds of rhenium labeled radiopharmaceuticals for therapy of the human brain glioma were prepared.Anti-human brain glioma monoclonal antibody (McAb-SZ39) was directly labeled with 186 ReO4^-.When ascorbic acid was used as reduction agent of antibody and the reduction of 186 ReO4^- was finished in sodium gluconate solution(pH=2.54),the labeling efficiency was 96.2%,After purification,the labeled products were tested in respect of immunoreactivity,in vitro stability as well as inhibitory efficiency against human glioma transplanted in nude mice,188ReO4^- labeled colloid was synthesized by using a two-step method.The size of radiocolloid particles was around 2-5μm,and the radiochemical yield was over 95%,Nude mice Experiments demonstrated that the inhibitory efficiency against human brain glioma of 188Re-collied and ^188 Re-McAb-SZ39 was 90% and 65% ,respectively.
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| 关 键 词： | 铼示踪 放射性药物 大脑恶性肿瘤 |
Rhenium labeled McAb-SZ39 and colloid |
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| ZU Jianhua,DONG Mo,LI Huiyuan,WU Yuanfang.Rhenium labeled McAb-SZ39 and colloid[J].Nuclear Science and Techniques,1999,10(4):197-202. |
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| Authors: | ZU Jianhua DONG Mo LI Huiyuan WU Yuanfang |
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| Abstract: | Two kinds of rhenium labeled
radiopharmaceuticals for therapy of the human |
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| Keywords: | Radiopharmaceuticals 186ReO4- 188ReO4- Label McAb-SZ39 Colloid |
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