Label-Free Fiber Optic Biosensors With Enhanced Sensitivity |
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Authors: | Jian Yang Sandhu P Wanguo Liang Chang-Qing Xu Yingfu Li |
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Affiliation: | McMaster Univ., Hamilton; |
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Abstract: | A sensitivity-enhanced long-period grating in-fiber Michelson interferometer with diameter-reduced cladding was proposed for the first time, and was also demonstrated as a label-free biosensor based on refractive index measurement. The cladding structure dependence of the sensitivity for antibody-antigen immuno-sensing was studied experimentally. The proposed biosensor has shown an 8.5-fold sensitivity enhancement as compared to sensors without cladding reduction. |
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