用于新药开发的新的蛋白质功能预测方法

简述了在蛋白质功能预测领域中的研究方法和最新研发工具所面临的挑战,并讨论蛋白质功能预测是如何改变药物开发进展的,具体包括:基于序列同源性分析的注释转移、序列基元和模式增加了注释转移的说服力、3D结构信息可以精炼注释转移、亚细胞定位、翻译后修饰、结合位点和功能残基、蛋白质之间的相互作用.

Novel Protein-function Prediction Methods to Assist Drug Discovery

This article mainly discusses the field of protein function pre ction and t the challenges, research approaches and recent developed he ways by which these issues change the process of drug di tools in scovery, including homology-based annotation transfer,sequence motifs and patterns, information on 3D structure, subcellular localization, posttranslational modifications, binding sites and functional residues, protein-protein interactions.