| 对乙氧基苯乙酸的合成研究 |
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| 引用本文： | 丛杉,王涛,沈德隆,孙娜波.对乙氧基苯乙酸的合成研究[J].精细化工中间体,2006,36(6):32-34,47. |
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| 作者姓名： | 丛杉 王涛 沈德隆 孙娜波 |
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| 作者单位： | 1. 浙江工业大学,化学工程与材料学院,浙江,杭州,310032
2. 浙江新迪国际食品有限公司,浙江,杭州,310006 |
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| 摘 要： | 以对羟基苯乙酸为原料,分别采用溴乙烷和硫酸二乙酯为醚化试剂,经Williamson醚化合成了对乙氧基苯乙酸。通过正交实验得出两条路线的较优合成条件:溴乙烷法中,n(对羟基苯乙酸)n∶(溴乙烷)=11∶.6,反应温度68℃,反应时间5h,收率85%左右;硫酸二乙酯法中,n(对羟基苯乙酸)n∶(硫酸二乙酯)n∶(氢氧化钠)=1∶2.5∶2.4,反应温度80℃,收率在90%以上。
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| 关 键 词： | 对乙氧基苯乙酸 溴乙烷 硫酸二乙酯 合成 |
| 文章编号： | 1009-9212（2006）06-0032-03 |
| 收稿时间： | 2006-10-18 |
| 修稿时间： | 2006-10-18 |
Synthesis of 4-Ethoxyphenylacetic Acid |
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| CONG Shan,WANG Tao,SHEN De-long,SUN Na-bo.Synthesis of 4-Ethoxyphenylacetic Acid[J].Fine Chemical Intermediates,2006,36(6):32-34,47. |
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| Authors: | CONG Shan WANG Tao SHEN De-long SUN Na-bo |
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| Affiliation: | 1.Institute of Pesticide, Zhejiang University of Technology, Hangzhou 310032, China; 2. Zhejiang Xindi International Food Co, Ltd, Hangzhou 310006, China |
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| Abstract: | 4-Ethoxyphenylacetic acid was synthesized from 4-hydroxyphenylacetic acid by the Williamson etherization reaction.Ethyl bromide and diethyl sulfate were used as etherization reagents,respectively.By experiments utilizing an orthogonal design,optimum synthesis conditions were obtained as follows: in the ethyl bromide route,the molar ratio of 4-hydroxyphenylacetic acid to ethyl bromide was 1 ∶ 1.6,the reaction temperature was 68℃,the reaction time was 5 h and the yield was about 85%.In the diethyl sulfate route,the molar ratio of 4-hydroxyphenylacetic acid to diethyl sulfate was 1 ∶ 2.5,the molar ratio of 4-hydroxyphenylacetic acid to sodium hydroxide was 1 ∶ 2.4,the reaction temperature was 80℃ and the yield was above 90%. |
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| Keywords: | 4-ethoxyphenylacetic acid ethyl bromide diethyl sulfate synthesis |
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