| 一种新型高效电化学发光免疫检测标记物三联吡啶钌衍生物的合成 |
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| 引用本文： | 杨夕强,赵文辉,夏万东.一种新型高效电化学发光免疫检测标记物三联吡啶钌衍生物的合成[J].化学试剂,2009,31(8). |
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| 作者姓名： | 杨夕强 赵文辉 夏万东 |
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| 作者单位： | 河北承德石油高等专科学校,化工系,河北,承德,067000 |
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| 摘 要： | 电化学发光免疫测定是电化学发光和免疫测定相结合的产物.它的标记物的发光原理是通过标记物与抗原或抗体连接,制成抗原、抗体标记物,然后在电极表面由电化学引发的特异性化学发光反应.三联吡啶钌衍生物为水溶性,在电化学发光反应中表现高效和稳定,被广泛应用于电化学发光免疫测定.探索了新型高效的三联吡啶钌的合成,以4,4′-二甲基-2,2′-联吡啶为原料,成功合成了双(2,2′-联吡啶)4-(4-甲基-4′-正丁酸)-2,2′-联吡啶]钌(Ⅱ)双六氟磷酸盐.
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| 关 键 词： | 电化学发光免疫测定 三联吡啶钌衍生物(2 2′-联吡啶) 双(2 2′-联吡啶)[4-(4-甲基-4′-正丁酸)-2 2′-联吡啶]钌(Ⅱ)双六氟磷酸盐 |
Synthesis of a new high performance labeled molecule of tris-(2,2'-bipyridine)(Ru-bipy) applied in electrochemiluminescence immunoassay |
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| YANG Xi-qiang,ZHAO Wen-hui,XIA Wan-dong.Synthesis of a new high performance labeled molecule of tris-(2,2'-bipyridine)(Ru-bipy) applied in electrochemiluminescence immunoassay[J].Chemical Reagents,2009,31(8). |
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| Authors: | YANG Xi-qiang ZHAO Wen-hui XIA Wan-dong |
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| Affiliation: | Department of Chemical Engineering;Chengde Petroleum College;Chengde 067000;China |
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| Abstract: | Electrochemiluminescence immunoassay(ECLI)is a combination of electrochemiluminescence(ECL)and immunoassay.The theory of labeled molecular luminescence is to synthesize labeled antigen or antibody by combining labeled molecules with antigen or antibody,followed by distinguishing the chemiluminescence resulted from electrochemical reactions on the surface of electrodes.Tris-(2,2'-bipyridine)(Ru-bipy)is widely applied in electrochemiluminescence immunoassay because of its water-solubility,high performance and... |
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