RUNX1: A MicroRNA Hub in Normal and Malignant Hematopoiesis |
| |
Authors: | Stefano Rossetti Nicoletta Sacchi |
| |
Affiliation: | Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, NY 14263, USA; E-Mail: |
| |
Abstract: | Hematopoietic development is orchestrated by gene regulatory networks that progressively induce lineage-specific transcriptional programs. To guarantee the appropriate level of complexity, flexibility, and robustness, these networks rely on transcriptional and post-transcriptional circuits involving both transcription factors (TFs) and microRNAs (miRNAs). The focus of this review is on RUNX1 (AML1), a master hematopoietic transcription factor which is at the center of miRNA circuits necessary for both embryonic and post-natal hematopoiesis. Interference with components of these circuits can perturb RUNX1-controlled coding and non-coding transcriptional programs in leukemia. |
| |
Keywords: | RUNX1 (AML1) microRNAs (miRNAs) hematopoiesis leukemia transcription factor-microRNA circuits gene regulatory networks |
|
|