| 可吸收 HA/PDLLA 内固定材料组织相容性观察 |
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| 引用本文： | 郭晓东,郑启新,杜靖远,曾晖,全大萍,闫玉华,李世普. 可吸收 HA/PDLLA 内固定材料组织相容性观察[J]. 武汉理工大学学报, 1998, 0(4) |
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| 作者姓名： | 郭晓东 郑启新 杜靖远 曾晖 全大萍 闫玉华 李世普 |
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| 作者单位： | 同济医科大学附属协和医院，武汉工业大学 |
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| 基金项目： | 湖北省科技攻关项目资助 |
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| 摘 要： | 可吸收骨折内固定材料要求具有很好的组织相容性。本文将自行研制的可吸收羟基磷灰石／聚ＤＬ乳酸（ＨＡ／ＰＤＬＬＡ）内固定材料植入兔肌肉和骨组织中，于３、６、１２、２４、３６、５２周取材，作ｘ线摄片和组织学观察。结果：骨折在６周内正常愈合，５２周内组织反应较轻，无大量炎性细胞集聚。结论：ＨＡ／ＰＤＬＬＡ复合材料具有很好的组织相容性。
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| 关 键 词： | 可吸收材料；聚DL乳酸；羟基磷灰石；组织相容性 |
Tissue Compatibility of Self designed Absorbable Hydroxyapatite/Poly(DL Lactide) Composites |
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| Guo Xiaodong Zheng Qixin Du Jingyuan Zen Hui Quan Dapin Yan Yuhua Li Shipu. Tissue Compatibility of Self designed Absorbable Hydroxyapatite/Poly(DL Lactide) Composites[J]. Journal of Wuhan University of Technology, 1998, 0(4) |
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| Authors: | Guo Xiaodong Zheng Qixin Du Jingyuan Zen Hui Quan Dapin Yan Yuhua Li Shipu |
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| Affiliation: | Guo Xiaodong Zheng Qixin Du Jingyuan Zen Hui Quan Dapin Yan Yuhua Li Shipu |
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| Abstract: | The long term tissue compatibility of self designed hydroxyapatite/poly(DL Lactide) (HA/PDLLA) fracture fixation devices were investigated in muscle or concellous bone in 30 rabbits.The follow up times were three, six, 12,24,36 and 52 weeks.Roentgenographic and histologic studies were done.The results showed that all osteotomies united within six weeks without delay.The tissue reaction was mild within 52 weeks for there was no accumulation of inflammatory cells.Consequently,The HA/PDLLA composites possess good tissue compatibiltity. |
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| Keywords: | bioabsorbable material poly(DL lactide) hydroxyapatite tissue compatibility |
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