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Urine proteomic studies in preeclampsia |
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| Authors: | Aggeliki Kolialexi Danai Mavreli Georgia Tounta Ariadni Mavrou Nikolas Papantoniou |
| Affiliation: | 1. Department of Medical Genetics, Athens University School of Medicine, Athens, Greece
The first two authors contributed equally to the study and should be both considered as first author. Correspondence: Aggeliki Kolialexi, Department of Medical Genetics, Athens University School of Medicine, Aghia Sofia Children's Hospital, Thivon & Levadias, 115 27, Athens, Greece E-mail: akolial@med.uoa.gr;2. Department of Medical Genetics, Athens University School of Medicine, Athens, Greece The first two authors contributed equally to the study and should be both considered as first author.;3. Department of Medical Genetics, Athens University School of Medicine, Athens, Greece;4. 3rd Department of Obstetrics & Gynecology, Athens University School of Medicine, Athens, Greece |
| Abstract: | Preeclampsia (PE) is a multisystem disorder of pregnancy that develops after 20 wk of gestation in previously normotensive women and complicates 5–8% of pregnancies. This rapidly progressive syndrome is usually diagnosed when the mother develops hypertension and proteinuria. The only effective treatment is delivery of the baby although early low-dose aspirin has been shown to significantly reduce the risk for PE. Recent advances in proteomic methods of protein separation, identification, and quantitation may allow for the identification of proteins and peptides that could facilitate early detection of disease, improve assessment of prognosis, and allow closer monitoring of women at risk for PE. This review summarizes all currently available markers for prediction and diagnosis of PE and presents urine proteomic studies performed for the identification of novel biomarkers. |
| Keywords: | Biomarkers Preeclampsia Urine proteomics |