A Triply Divergent Reagent for Glycoprotein Synthesis |
| |
| Authors: | Sonia De Munari Torben Schiffner Benjamin G. Davis |
| |
| Affiliation: | 1. Department of Chemistry, University of Oxford, Mansfield Road, Oxford, OX1 3TA (UK), Phone: (+44) 01865 275652;2. The Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, OX1 3RE (UK) |
| |
| Abstract: | Chemical synthesis of glycoproteins through three different strategies, from the same reagent, is herein described. The flexibility of this system, which allows the comparison of different linkage motifs between the same glycan and protein, is shown by one-step diversification of a GlcNAc-ylating reagent and its application in both site-specific and non-site-specific glycoprotein synthesis to create different conjugates from common representative protein scaffolds. |
| |
| Keywords: | glycoconjugates glycoproteins glycosylation protein modifications tag-and-modify |
|
|
