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Proteomics in the investigation of HIV-1 interactions with host proteins |
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| Authors: | Ming Li |
| Affiliation: | Laboratory of Retrovirology, Division of Infectious Diseases, Department of Medicine, Alpert Medical School of Brown University, Providence, RI USA
Correspondence: Dr. Ming Li, 55, Claverick Street, Room 432, Providence, RI 02903, USA E-mail: ming.li@brown.edu Fax: +1-401-444-2939 |
| Abstract: | Productive HIV-1 infection depends on host machinery, including a broad array of cellular proteins. Proteomics has played a significant role in the discovery of HIV-1 host proteins. In this review, after a brief survey of the HIV-1 host proteins that were discovered by proteomic analyses, I focus on analyzing the interactions between the virion and host proteins, as well as the technologies and strategies used in those proteomic studies. With the help of proteomics, the identification and characterization of HIV-1 host proteins can be translated into novel antiretroviral therapeutics. |
| Keywords: | Cellular factor HIV-1 Host protein MS Viral protein |