Effects of dicarboxylic acids on fatty acid-metabolizing enzymes in cultured rat hepatocytes |
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Authors: | T Sato N Murayama Y Yamazoe R Kato |
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Affiliation: | Department of Pharmacology, Keio University, Tokyo, Japan. |
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Abstract: | A clear chain-length dependent effect was observed for peroxisomal fatty acid beta-oxidation and carnitine acetyltransferase and also for mitochondrial carnitine palmitoyltransferase in primary cultures of rat hepatocytes. The extent of modulation of peroxisomal beta-oxidation was higher with even-carbon numbered dicarboxylic acids than with odd-carbon numbered ones, although such a tendency was not detected in the mitochondrial reactions. These results indicate difference in the effect of fatty acid-derived dicarboxylates on peroxisomal and mitochondrial functions. |
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