Phase I clinical trial of the flavonoid quercetin: pharmacokinetics and evidence for in vivo tyrosine kinase inhibition |
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Authors: | DR Ferry A Smith J Malkhandi DW Fyfe PG deTakats D Anderson J Baker DJ Kerr |
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Affiliation: | Department of Clinical Neuroscience, G?teborg University, M?lndal, Sweden. |
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Abstract: | In the present open study, the long-term safety, tolerability, and efficacy of citalopram in the treatment of elderly people with emotional disturbances were studied. One hundred twenty-three elderly patients with symptoms of depression-anxiety were included. Most of the patients (76%) were demented. Fifty-two patients completed a 12-month treatment. Irritability, depressed mood, anxiety, restlessness, and fear-panic were significantly reduced. The severity of illness from baseline to Month 9 was rated as significantly improved. The side effects were infrequent and mostly mild. |
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