Difference in binding of killed and live Streptococcus pneumoniae serotypes by C-reactive protein |
| |
| Authors: | AJ de Beaufort JA Langermans AM Matze-van der Lans PS Hiemstra JM Vossen R van Furth |
| |
| Affiliation: | Department of Paediatrics, Leiden University Hospital, The Netherlands. |
| |
| Abstract: | The binding and opsonic properties of C-reactive protein (CRP) for various species of bacteria were investigated. CRP bound more avidly to killed than to live Streptococcus pneumoniae, the binding varying among various serotypes; CRP hardly bound to a number of other bacterial species studied. CRP enhanced complement-dependent phagocytosis of live S. pneumoniae by granulocytes but did not enhance the phagocytosis of live Staphylococcus aureus or group B streptococci. We suppose that CRP may serve as an opsonin for killed bacteria and bacterial debris but is probably not an important opsonin for live bacteria other than S. pneumoniae. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
