Accumulation of acetone in blood during long-term anaesthesia with closed systems |
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Authors: | JM Strauss J Hausd?rfer |
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Affiliation: | Department of Anaesthesia III, Medizinische Hochschule Hannover, Germany. |
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Abstract: | During closed system anaesthesia with isoflurane, patients with a preoperative increase in blood concentration of acetone (> 10 mg litre-1) had a significantly greater concentration of acetone than patients with an initial normal blood concentration of acetone (P < 0.01). Flushing the closed system with a high flow of fresh gas had no effect on the blood concentration of acetone. Using a large fresh gas flow, there was no increase in blood acetone concentration. Acetone concentrations of about 50 mg litre-1 cause problems such as nausea and vomiting in the postoperative period. These symptoms occurred more frequently after closed system anaesthesia. |
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